Mitochondrial quality control in hepatic ischemia-reperfusion injury

Hepatic ischemia-reperfusion injury is a phenomenon in which exacerbating damage of liver cells due to restoration blood flow following ischemia during surgery, especially those involving transplantation. Mitochondria, the energy-producing organelles, are crucial for cell survival and apoptosis have evolved range quality control mechanisms maintain homeostasis mitochondrial network response various stress conditions. leads disruption mechanisms, as evidenced by reduced autophagy, excessive division, fusion, inhibition biogenesis. This dysfunction network. The accumulation damaged mitochondria ultimately results hepatocytes release apoptotic proteins like cytochrome C. worsens hepatic injury. Currently, protection being studied using different approaches such drug pretreatment, stem exosomes, genetic interventions, mechanical reperfusion, all aimed at targeting mechanisms. paper aims provide direction future research on combating HIRI reviewing latest studies that focus